The development of fibers with desired drug release properties has gained a high research interest for water-soluble drugs with controlled drug delivery systems obtained by coaxial electrospinning technique. The objective of this study is to achieve the controlled-release of doxycycline hyclate (DOXH) from the fabricated electrospun fibers. In this case, three different electrospun core/shell fibers have been successfully fabricated using this technique and the model drug, DOXH, has been entrapped in the core layers. The results of the structural properties and in vitro release studies have been compared with electrospun monostructural fibers fabricated by conventional electrospinning technique. Scanning electron microscopy and transmission electron microscopy images have proved that the fabricated electrospun fibers have core/shell structures. Fourier transform infrared spectroscopy has shown convenient interaction and compatibility between polymers and the model drug. X-ray diffraction analysis has revealed that all the encapsulated DOXH are transferred into amorphous physical state and lost its crystalline state in the fibers. Moreover, drug release studies have demonstrated that the electrospun core/shell fibers show a better-controlled release than the monostructural fibers. It can be concluded that the fibers obtained by blending hydrophilic and hydrophobic polymers such as poly(ε-caprolactone) and poly(ethylene oxide) in both shell and core sides are promising candidate for controlled drug release. 相似文献
The objective of this study is to design storage assignment and order picking system using a developed mathematical model and stochastic evolutionary optimization approach in the automotive industry. It is performed in two stages. At the first stage, storage location assignment problem is solved with a class-based storage policy with the aim of minimizing warehouse transmissions by using integer programming. At the second stage, batching and routing problems are considered together to minimize travel cost in warehouse operations. A warehouse in the automotive industry is analyzed, and an optimum solution is obtained from an integer programming model. Due to the computational time required for solving the integer programming problem, a faster genetic algorithm is also developed to form optimal batches and optimal routes for the order picker. The main advantage of the algorithm is the quick response to production orders in real-time applications. The solutions showed that the proposed approach based on genetic algorithms can be applied and integrated to any kind of warehouse layout in automotive industry. 相似文献
Iron mineralizations in the study area are found in amphibolites in the localities of Buyukoren,Uzunkuyu-Atkayasi,and Karabacak and they display a predominantly banded texture.Their paragenesis is dominated by magnetite and hematite.In this study,iron mineralizations in Sarikaya were examined in terms of rare earth element(REE) contents and attempts were made to determine some physicochemical conditions that had an impact upon their formation.For this purpose,42 ore samples and 17 enriched magnetite samples... 相似文献
Summary
N-vinyl 2-pyrrolidone (VP) / Acrylonitrile (AN) copolymeric hydrogels were synthesized by using γ-radiation and amidoximated
for the purpose of uranyl ion adsorption. Optimum amidoximation time was determined by following the uranyl ion, UO22+, adsorption capacity. The adsorption of amidoximated copolymers was studied from different uranyl ion solutions (1000–1850
ppm). The results of all adsorption studies showed that the interaction between UO22+ and amidoxime groups comply with Langmuir type isotherm. The adsorption capacity was found as 0.54 g UO22+ /g dry amidoximated copolymeric hydrogels. From the stoichiometric calculations, it was found that the bonding between UO22+ and amidoxime groups is 1 to 4.
Received: 7 September 1999/Revised version: 21 February 2000/Accepted: 18 March 2000 相似文献
The aim of this paper is to obtain communication resource based on the overlay method for the secondary user (SU) in the primary communication environment operating in the Stop-and-Wait Hybrid Automatic Repeat Request (SW-HARQ) protocol. Unlike the overlay Cognitive Radio applications in the literature, in this work communication resources have been obtained for the SU in the time period in which the primary user (PU) is active in the channel. Our performance results have shown that a significant amount of sources of communication can be achieved for the SU by evaluating the waiting times in the primary SW HARQ periods, even when the PU is continuously running in the SW HARQ protocol without emptying the channel.